The show's plot

Patricia Williamson (Jade Ramsey), Joy's (Klariza Clayton) best friend, is dismayed to discover Joy has left without a trace and accuses Nina Martin (Nathalia Ramos) of being involved with Joy's disappearance. Nina, Patricia's new roommate, takes Joy's place in the same dorm room that Joy stayed in with Patricia. Nina later meets a senior citizen named Sarah Frobisher-Smythe (Rita Davies), who had lived in the house several years earlier. Sarah's parents were archaeologists in Egypt who mysteriously died. Out of frustration and spite for Nina, Patricia forces Nina to spend a night in the attic of the house as a sort of initiation. She is scared at first, but realizes that she somehow has a connection to the house. A necklace, shaped as the Eye of Horus, was given to Nina by Sarah. The locket seems to have a connection to the house as well and it opens secret doors and such as if by magic. Coupled with this and her new-found sense of intuition, Nina makes numerous more trips to the attic.

Nina later discovers wax cylinders hidden in the attic revealing that the house has a secret history and holds a mystery that is unknown to anyone. She decides to investigate it, alongside her new friend Fabian Rutter (Brad Kavanagh) and new roommate Amber Millington (Ana Mulvoy Ten). They form a secret group called "Sibuna," or Anubis backwards. The group eventually expands to include Patricia Williamson, who makes peace with Nina once they find out that the mystery of Joy's disappearance and the mystery of the house are somehow connected, and Alfie Lewis (Alex Sawyer), a prankster in the beginning of the series. The five teens team together to search for the treasure that is hidden within Anubis House and uncover the mystery behind the school as well as the disappearance of Joy. Soon, out of spite for and frustration from numerous sources, Jerome, Alfie's close friend and fellow prankster, falls out with Sibuna and joins the enemy, Rufus Zeno, who wants to use the house's treasure for evil purposes. Jerome eventually joins Sibuna after double-crossing Rufus and he helps lure Rufus into a trap. Mara Jaffray (Anastasia Dhanraj) and Mick Campbell (Bobby Lockwood), who have begun a relationship, deal with the everyday lives of a teenager while they have no knowledge of the mystery or Sibuna all throughout the first season.